L-Citrulline – Benefits, Effects and How to Use It

l citrulline benefits effects

What is L-Citrulline ?

L-citrulline is the main amino acid used by the body to make proteins. It is abundant in watermelons.

When consumed, the compound is converted to several other key amines that increase blood flow to the brain.

In addition to stimulating blood flow, L-Citrulline can increase energy levels in the body and reduce symptoms of fatigue.

Although Citrulline has few known side effects, its by-product L-Arginine presents some risks, which will be described in more detail below.


Effect of Citrulline on Your Body

When consumed, Citrullin becomes a precursor to L-arginine.

A precursor (sometimes used as a precursor) in organic chemistry is a substance, a chemical compound that reacts to produce another chemical compound.

This compound is well known for its supportive role in blood and heart health. It lowers blood pressure by dilating blood vessels, helping to remove any blockages.

This circulation effect affects systems throughout the body, including sexual health, wound healing, and inflammation pain. It also increases the amount of growth hormone in the body.

Citrulline is also converted to nitric acid. This compound further increases blood flow through the arteries. All of these functions in the brain help maintain healthy nerve function, especially when it comes to memory.

Increased cerebral blood flow helps to supply nutrients to, and maintains, nerve tissue and promotes rapid growth of neuronal structures such as synapses and neurons. This is similar to the nerve circulation effects caused by the natural herbal supplement Vinpocetine.

L-Citrulline Benefits

Citrulline stimulates circulation and the release of human growth hormone. This can increase resistance to injury and illness. The dietary supplement maintains strong immunity in all body systems. It speeds up healing from incisions and surgeries. It also contributes to bone strength.


Best L-Citrulline Supplement


How Much L-Citrulline to Take

Since this dietary supplement is still not widely used, there are several ready-made studies that detail the appropriate doses. There seem to be many effective doses, from 2 grams to 15 grams per day. An average dose of 6 grams is recommended for use in weight loss and exercise programs.


L-Citrulline Side Effects

Citrulline is considered very safe and has no known side effects.

However, it is important not to take prescription medicines for high blood pressure. Adding this additive can lower your blood pressure to dangerous concentrations.

In addition, any medication for erectile dysfunction such as Viagra or Cialis should be discontinued while taking citrulline. Low blood pressure can occur. Pregnant or breastfeeding women are advised not to take.

L-arginine (an amino acid synthesized from L-citrulline) has some side effects when considered as a separate agent. In some people, too much arginine can cause digestive problems like diarrhea and abdominal pain. It can also cause allergic sensitization and activate asthma attacks. Arginine has the same contraindications for blood pressure as above.



Citrulline is a natural amino acid that the body converts to L-Argnine and nitric acid. These compounds work to increase blood circulation throughout the body, including the brain. These effects can lead to increased immunity, more energy and better functioning of the heart. It also contributes to strong neurological tissue with excellent memory and concentration effects.

  1. Fike CD, Summar M, Aschner JL. L-citrulline provides a novel strategy for treating chronic pulmonary hypertension in newborn infants. Acta Paediatr. 2014
  2. El-Hattab AW, Emrick LT, Chanprasert S, Craigen WJ, Scaglia F. Mitochondria: role of citrulline and arginine supplementation in MELAS syndrome. Int J Biochem Cell Biol. 2014
  3. Lorin J, Zeller M, Guilland JC, Cottin Y, Vergely C, Rochette L. Arginine and nitric oxide synthase: regulatory mechanisms and cardiovascular aspects. Mol Nutr Food Res. 2014
  4. Dai Z, Wu Z, Yang Y, Wang J, Satterfield MC, Meininger CJ, Bazer FW, Wu G. Nitric oxide and energy metabolism in mammals. Biofactors. 2013
  5. Kaore SN, Amane HS, Kaore NM. Citrulline: pharmacological perspectives and its role as an emerging biomarker in future. Fundam Clin Pharmacol. 2013
  6. Cynober L, de Bandt JP, Moinard C. Leucine and citrulline: two major regulators of protein turnover. World Rev Nutr Diet. 2013
  7. Sureda A, Pons A. Arginine and citrulline supplementation in sports and exercise: ergogenic nutrients? Med Sport Sci. 2012
  8. Bahri S, Zerrouk N, Aussel C, Moinard C, Crenn P, Curis E, Chaumeil JC, Cynober L, Sfar S. Citrulline: from metabolism to therapeutic use. Nutrition. 2013
  9. El-Hattab AW, Emrick LT, Craigen WJ, Scaglia F. Citrulline and arginine utility in treating nitric oxide deficiency in mitochondrial disorders. Mol Genet Metab. 2012
  10. Bescós R, Sureda A, Tur JA, Pons A. The effect of nitric-oxide-related supplements on human performance. Sports Med. 2012
  11. Curis E, Crenn P, Cynober L. Citrulline and the gut. Curr Opin Clin Nutr Metab Care. 2007
  12. Moinard C, Cynober L. Citrulline: a new player in the control of nitrogen homeostasis. J Nutr. 2007
  13. Romero MJ, Platt DH, Caldwell RB, Caldwell RW. Therapeutic use of citrulline in cardiovascular disease. Cardiovasc Drug Rev. 2006
  14. Curis E, Nicolis I, Moinard C, Osowska S, Zerrouk N, Bénazeth S, Cynober L. Almost all about citrulline in mammals. Amino Acids. 2005
  15. Sharif Kashani B, Tahmaseb Pour P, Malekmohammad M, Behzadnia N, Sheybani-Afshar F, Fakhri M, Chaibakhsh S, Naghashzadeh F, Aidenlou S. Oral l-citrulline malate in patients with idiopathic pulmonary arterial hypertension and Eisenmenger Syndrome: a clinical trial. J Cardiol. 2014
  16. Hol JW, van Lier F, Valk M, Klimek M, Stolker RJ, Fekkes D. Effect of major and minor surgery on plasma levels of arginine, citrulline, nitric oxide metabolites, and ornithine in humans. Ann Surg. 2013
  17. Sanchez-Gonzalez MA, Koutnik AP, Ramirez K, Wong A, Figueroa A. The effects of short term L-citrulline supplementation on wave reflection responses to cold exposure with concurrent isometric exercise. Am J Hypertens. 2013
  18. van der Velden WJ, Herbers AH, Brüggemann RJ, Feuth T, Peter Donnelly J, Blijlevens NM. Citrulline and albumin as biomarkers for gastrointestinal mucositis in recipients of hematopoietic SCT. Bone Marrow Transplant. 2013
  19. Balderas-Munoz K, Castillo-Martínez L, Orea-Tejeda A, Infante-Vázquez O, Utrera-Lagunas M, Martínez-Memije R, Keirns-Davis C, Becerra-Luna B, Sánchez-Vidal G. Improvement of ventricular function in systolic heart failure patients with oral L-citrulline supplementation. Cardiol J. 2012
  20. Jabecka A, Ast J, Bogdaski P, Drozdowski M, Pawlak-Lemaska K, Cielewicz AR, Pupek-Musialik D. Oral L-arginine supplementation in patients with mild arterial hypertension and its effect on plasma level of asymmetric dimethylarginine, L-citruline, L-arginine and antioxidant status. Eur Rev Med Pharmacol Sci. 2012
  21. Lin YJ, Hsu CN, Lo MH, Huang CF, Chien SJ, Tain YL. High citrulline-to-arginine ratio associated with blood pressure abnormalities in children with early chronic kidney disease. Circ J. 2013
  22. Thibault R, Flet L, Vavasseur F, Lemerle M, Ferchaud-Roucher V, Picot D, Darmaun D. Oral citrulline does not affect whole body protein metabolism in healthy human volunteers: results of a prospective, randomized, double-blind, cross-over study. Clin Nutr. 2011
  23. Kameda N, Okigawa T, Kimura T, Fujibayashi M, Asada T, Kinoshita R, Baba S, Morita M, Morishita K, Moritani T. The effect of L-citrulline ingestion on ECG QT interval and autonomic nervous system activity. J Physiol Anthropol. 2011
  24. Cormio L, De Siati M, Lorusso F, Selvaggio O, Mirabella L, Sanguedolce F, Carrieri G. Oral L-citrulline supplementation improves erection hardness in men with mild erectile dysfunction. Urology. 2011
  25. Orozco-Gutiérrez JJ, Castillo-Martínez L, Orea-Tejeda A, Vázquez-Díaz O, Valdespino-Trejo A, Narváez-David R, Keirns-Davis C, Carrasco-Ortiz O, Navarro-Navarro A, Sánchez-Santillán R. Effect of L-arginine or L-citrulline oral supplementation on blood pressure and right ventricular function in heart failure patients with preserved ejection fraction. Cardiol J. 2010
  26. Ochiai M, Hayashi T, Morita M, Ina K, Maeda M, Watanabe F, Morishita K. Short-term effects of L-citrulline supplementation on arterial stiffness in middle-aged men. Int J Cardiol. 2012
  27. Orea-Tejeda A, Orozco-Gutiérrez JJ, Castillo-Martínez L, Keirns-Davies C, Montano-Hernández P, Vázquez-Díaz O, Valdespino-Trejo A, Infante O, Martínez-Memije R. The effect of L-arginine and citrulline on endothelial function in patients in heart failure with preserved ejection fraction. Cardiol J. 2010
  28. Sureda A, Córdova A, Ferrer MD, Pérez G, Tur JA, Pons A. L-citrulline-malate influence over branched chain amino acid utilization during exercise. Eur J Appl Physiol. 2010
  29. Pérez-Guisado J, Jakeman PM. Citrulline malate enhances athletic anaerobic performance and relieves muscle soreness. J Strength Cond Res. 2010
  30. Figueroa A, Trivino JA, Sanchez-Gonzalez MA, Vicil F. Oral L-citrulline supplementation attenuates blood pressure response to cold pressor test in young men. Am J Hypertens. 2010
  31. Sureda A, Cordova A, Ferrer MD, Tauler P, Perez G, Tur JA, Pons A. Effects of L-citrulline oral supplementation on polymorphonuclear neutrophils oxidative burst and nitric oxide production after exercise. Free Radic Res. 2009
  32. Schwedhelm E, Maas R, Freese R, Jung D, Lukacs Z, Jambrecina A, Spickler W, Schulze F, Böger RH. Pharmacokinetic and pharmacodynamic properties of oral L-citrulline and L-arginine: impact on nitric oxide metabolism. Br J Clin Pharmacol. 2008
  33. Waugh WH, Daeschner CW 3rd, Files BA, McConnell ME, Strandjord SE. Oral citrulline as arginine precursor may be beneficial in sickle cell disease: early phase two results. J Natl Med Assoc. 2001

Leave a Reply

Your email address will not be published. Required fields are marked *